Jackson Martinez is in line to make his first Atletico Madrid appearance for a month when Diego Simeone's men seek to build on their slender Copa del Rey first-leg advantage at home to Reus Deportiu.
The joint Liga leaders found themselves trailing at the Estadio Camp Nou Municipal when Fran Carbia took advantage of some sloppy defending to put third-tier Reus in front.
Luciano Vietto and Saul Niguez responded to put the Segunda B Group 3 outfit behind in the fourth-round tie and extra firepower could be on the agenda in the return, courtesy of Martinez.
The former Porto striker has missed Atleti's past seven matches since suffering a sprained ankle while on international duty with Colombia last month.
But he played a full part in training on Tuesday and, according to local media reports, lined up alongside Fernando Torres to spearhead the attack in a likely line-up for Thursday's match.